Right Patients,
Right Time

Our off-the-shelf approach allows us to investigate our precision vaccines alongside the standard of care for a given cancer type at any timepoint in a patient’s cancer treatment journey.

ITOP1
Oesophageal Adenocarcinoma
Trial Commenced Q4'25
ITOP2
Cancer #2
Target selection Q3’26
ITOP3
Cancer #3
Scheduled H2’26
ITOP4
Cancer #4
ITOP5
Cancer #5

The accelerated regulatory route enabled by our MHRA-awarded Innovative Licensing and Access Pathway (ILAP) passport, has allowed us to initiate our
first-in-human VISTA study: a randomised, placebo-controlled, double-blind phase 1/2a trial in resectable oesophageal adenocarcinoma. This is a population with high unmet need, with half of patients experiencing recurrence within 2-3 years of surgery. Our off-the-shelf design means we can intervene at the earliest opportunity, with the first dose given before the tumour is surgically removed.

VISTA is designed to provide rapid proof-of-concept for our Precision ImmunomicsTM antigen discovery platform and our proprietary vector platform. We are actively exploring partnership and collaboration opportunities to accelerate expansion into an initial 4 additional cancers covering a $45 billion addressable market.

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